Sugar’s Effects on Skin: Glycation and AGEs
Aging is a natural process, but excessive sugar speeds it up in multiple ways.
When sugar enters the bloodstream, it binds to proteins like collagen and elastin through a process called glycation, forming harmful molecules known as Advanced Glycation End Products (AGEs).
These AGEs damage your collagen and reduce skin elasticity, increasing visible signs of aging. Additionally, AGEs increase oxidative stress and inflammation, which further weaken the skin’s structural integrity and resilience.
In addition to glycation, high sugar accelerates aging by damaging protective caps on DNA called telomeres, which shorten as cells divide. This shortening process is a natural part of growing older, but excessive sugar intake speeds up telomere shortening, further contributing to premature aging.
Key effects of sugar on the skin include:
- Loss of Firmness: Glycation breaks down collagen and elastin, causing sagging skin, especially around the chin and neck.
- Fine Lines and Wrinkles: AGEs stiffen collagen, making skin less flexible and therefore more prone to fine lines and wrinkles.
- Inflammation: Sugar-related glycation can worsen acne and redness by increasing inflammation. This can lead to clogged pores and increase risk of breakouts.
- Oxidative Stress: High sugar intake elevates oxidative stress, accelerating overall skin cell damage.
- Dehydration: Excessive sugar can dehydrate skin by drawing water out of cells, leading to dryness, dullness, and an increase in visible fine lines.



























2 comments
Angela Reid
I placed my first trifecta order and am very excited to try it. I have been using Enrich and love the product which is high quality and I had immediate great results.
Wondering about the trifecta and do I immediately start to use it twice a day every day? Or is it necessary to gradually ease into it?
Thanks,
Angela
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KaramMD Skin replied:
Hi Angela—Thanks for your comment! While the Trifecta is formulated to be gentle and effective, it does contain active ingredients that can take a little time for your skin to adjust to, especially if you’re just starting out. Dr. Karam always recommends easing into any new skincare routine, especially for those with sensitive skin. To start, introduce each product to your skin with a patch test. If you’re concerned about irritation, a gentle approach is to use Illuminate just once a day to start (preferably in the evening), and see how your skin responds. Your patience will definitely pay off!
Susan
Cosmetic or plastic surgeon
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KaramMD Skin replied:
Hi Susan—Dr. Karam is a facial plastic surgeon. You can learn more about his clinical practice on his website drkaram.com.
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