KaramMD Trifecta

The Complete Anti-Aging Routine

4.7
Rated 4.7 out of 5 stars
1,289 Reviews

A simple skincare system proven to give you healthier, younger-looking skin in 3 easy steps—formulated with powerful active ingredients to target all aspects of aging skin simultaneously.

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MD Formulated

Clinically Proven

Premium Ingredients

For All Skin Types

Cruelty Free

Clinically Proven to Fight Aging Skin

The Trifecta system visibly reduces signs of aging in as little as 4 weeks when used consistently. We adhere to the highest product standards and validate efficacy through rigorous third-party testing. After 8 weeks of usage, the clinical study proved:

100% of subjects had improvement in skin’s moisture.

100% of subjects had improvement in fine lines & wrinkles.

91% of subjects had improvement in skin’s firmness.

Clinically Proven to Fight Aging Skin

The Trifecta system visibly reduces signs of aging in as little as 4 weeks when used consistently. We adhere to the highest product standards and validate efficacy through rigorous third-party testing. After 8 weeks of usage, the clinical study proved:

100% of subjects had improvement in skin’s moisture.

100% of subjects had improvement in fine lines & wrinkles.

91% of subjects had improvement in skin’s firmness.

Truly Innovative
Anti-Aging Formulas

1. POWERFUL YET GENTLE
Meticulously crafted to ensure the right combination of anti-aging ingredients, gentle enough for even the most sensitive skin.


2. COMPREHENSIVE RESULTS, SIMPLIFIED
Our formulations consolidate up to 10 products into a 3-step routine, fundamentally addressing all aspects of aging simultaneously.


3. TARGETED ANTI-AGING ESSENTIALS
Premium ingredients and potent actives scientifically proven to prevent or reverse signs of aging and targeted to make changes on the cellular level.

Truly Innovative
Anti-Aging Formulas

1. POWERFUL YET GENTLE
Meticulously crafted to ensure the right combination of anti-aging ingredients, gentle enough for even the most sensitive skin.


2. COMPREHENSIVE RESULTS, SIMPLIFIED
Our formulations consolidate up to 10 products into a 3-step routine, fundamentally addressing all aspects of aging simultaneously.


3. TARGETED ANTI-AGING ESSENTIALS
Premium ingredients and potent actives scientifically proven to prevent or reverse signs of aging and targeted to make changes on the cellular level.

Great Skin Made Simple

The Trifecta was developed by world renowned skin and facial rejuvenation expert Dr. Amir Karam. This routine is formulated with only the best high-quality ingredients, and designed to deliver results that only get better over time. Learn more about the creation of the Trifecta. 

Great Skin Made Simple

The Trifecta was developed by world renowned skin and facial rejuvenation expert Dr. Amir Karam. This routine is formulated with only the best high-quality ingredients, and designed to deliver results that only get better over time. Learn more about the creation of the Trifecta. 

How to Use

Rinse: Apply to wet skin, massage in circular motions, then rinse clean.

Quench: Apply 2 pumps to slightly damp face, eye area, and neck.

Illuminate: Apply 3 pumps to face, eye area, and neck.

Repeat this routine morning and night--do not skip applications. Consistent use for a minimum of 3-6 months for visible, lasting change.

HOW TO USE: TRIFECTA ROUTINE

How to Use

Rinse: Apply to wet skin, massage in circular motions, then rinse clean.

Quench: Apply 2 pumps to slightly damp face, eye area, and neck.

Illuminate: Apply 3 pumps to face, eye area, and neck.

Repeat this routine morning and night--do not skip applications. Consistent use for a minimum of 3-6 months for visible, lasting change.

HOW TO USE: TRIFECTA ROUTINE

Read the KaramMD Journal

Skincare Advice You Can Trust

The Best Anti-Aging Ingredients

The Best Anti-Aging Ingredients

When assessing your skincare products, it is essential they include the following anti-aging ingredients. Each of these ingredients play a unique role in skin health and are crucial to achieving y...

Dr. Karam's Philosophy for an Effective Skincare Routine

Dr. Karam's Philosophy for an Effective Skincare Routine

I believe I’ve finally found the secret to anti-aging. After 20 years of experience—and a lot of patience (and patients) throughout my career—I came to understand that skincare is more than just t...

KaramMD Trifecta skincare routine: Rinse Daily Cleanser, Quench Vitamin C Serum, and Illuminate Anti-Aging Cream held in a single hand.

Trifecta 101: What You Need to Know When Starting Your New Skincare Routine

Whether you’re completely new to skincare or transitioning to the Trifecta system, this guide will walk you through what to expect as you begin your skincare journey.

INGREDIENTS

Aloe Barbadensis (Aloe Vera) Leaf Juice*, Aqua/Water/Eau, Lauryl Glucoside, Glycerin, Cocamidopropyl Betaine, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Allantoin, Sodium Cocoyl Apple Amino Acids, Brassica Oleracea Italica (Broccoli) Seed Oil, Epilobium Angustifolium (Fireweed) Flower/Leaf/Stem Extract, Cocamidopropyl Dimethylamine, Arnica Montana (Mountain Arnica) Flower Extract, Phenoxyethanol, Sodium Chloride, Caprylyl Glycol, Hexylene Glycol, Sodium Hydroxide, Ethylhexylglycerin, Sodium Phytate, Glycolic Acid, Dimethylaminopropylamine, Dichloroacetic Acid, Tetrasodium Glutamate Diacetate, Alcohol, Sodium Metabisulfite, Fragrance/Parfum, Limonene, Geraniol, Hexyl Cinnamal, Linalool.

*Organic Ingredient

Frequently Asked Questions

Our caring team of experts has the answers.

4.7
Rated 4.7 out of 5 stars
Based on 1,289 reviews
1,289 reviews
  • SS
    Scotland S.
    Verified Buyer
    34 minutes ago
    Rated 5 out of 5 stars
    “No Filters Needed — My Skin’s Never Looked Better

    I rarely write reviews, but the Karam MD Trifecta Facial Care System deserves all the praise. I’ve been using it consistently for months now, and the transformation in my skin is undeniable.

    My complexion looks brighter, more even, and — no exaggeration — healthier overall. There's this bounce and firmness to my skin that I haven’t felt in years. Friends and family have commented on how “refreshed” or “well-rested” I look, which I take as the ultimate compliment because trust me, I’m not getting more sleep!

    What I love most is how this system takes the guesswork out of skincare. Each product works seamlessly together, and it doesn’t feel overwhelming or like a chore to stick with it. The texture of the formulas is luxurious, and I actually look forward to using them. As someone who’s tried countless routines over the years, I can confidently say this one delivers. It’s elegant, effective, and worth every bit of hype.

    P.S. Dr. Karam — if you ever see this, we would love a travel-size version of the Trifecta system! I know the current sizes are technically travel-appropriate, but when space really counts, some littles for grab-and-go would be a total dream.

    KS Profile picture for KaramMD Skin
    KaramMD Skin
    12 seconds ago

    Thank you for your wonderful review, Scotland! We're absolutely thrilled to hear about your transformative journey with the Trifecta. It's particularly touching to hear about the remarkable improvements you've experienced—from the enhanced brightness and evenness to that youthful bounce and firmness you're seeing in your skin. These are exactly the kind of results we aim for with our formulations! We love that others are noticing your radiant transformation too, with those wonderful comments about looking refreshed and well-rested. Your appreciation of our system's seamless integration and user-friendly approach truly validates our commitment to creating effective, uncomplicated skincare solutions. And thank you for that thoughtful suggestion about travel sizes—we love hearing ideas from our dedicated customers! Your enthusiasm and trust in our products mean the world to us, and we're deeply grateful to have you as part of the KaramMD Skin community. Thank you for taking the time to share your inspiring experience with us!

  • EF
    Eva Fountain M.
    Verified Buyer
    3 hours ago
    Rated 5 out of 5 stars
    Trifecta really works

    I am 75 years old & have always tried to use the best skincare products & also RetinA. Trifecta really works. I have only been using it since February 2025. I love the way my skin is changing for the good. Pores are shrinking, dark spots are lightening at this point, skin is brighter & feels smooth. I’m very pleased with trifecta. It is costly but considering you only use the trio once or twice a day & it is so easy to use. I’m so glad I saw Dr Karan’s skincare video on YouTube. I get compliments all the time saying I look years younger! Makes my day!

    KS Profile picture for KaramMD Skin
    KaramMD Skin
    3 hours ago

    Thank you for your wonderful review, Eva ! We're absolutely thrilled to hear about your amazing journey with Trifecta and how it's transforming your skin. It's particularly touching to hear about the significant improvements you've experienced—from shrinking pores and lightening dark spots to brighter, smoother skin—these are exactly the kind of transformative results we aim for with our formulations. We love that you've noticed such positive changes and are receiving compliments about looking years younger! Your perspective on the value of the system, especially as someone with extensive experience using high-quality skincare products, truly validates our commitment to creating exceptional skincare solutions. We're deeply moved by your trust in our products and Dr. Karam's expertise, and we're honored to have you as part of the KaramMD Skin community. Thank you for sharing your inspiring experience with us!

  • KB
    Karen B.
    Verified Buyer
    3 hours ago
    Rated 5 out of 5 stars
    Soft, Glowing, Healthy skin!

    So far so good! I just started month 3, and am impressed with how healthy and glowing my skin looks and feels. I have very large pores, and have enjoyed less congestion, and diminished pore size. I look forward to seeing the impact on fine lines and wrinkles! This system is so quick and easy to use - it is easy to stay consistent. I haven't missed one application!

    KS Profile picture for KaramMD Skin
    KaramMD Skin
    3 hours ago

    Thank you for your wonderful review, Karen ! We're absolutely thrilled to hear about your amazing three-month journey with Trifecta. It's particularly touching to hear about the significant improvements you've experienced with your pore size and skin congestion—these are exactly the kind of transformative results we aim for with our formulations. We love that you've noticed such positive changes in your skin's health and glow! Your dedication to consistency with the system is truly inspiring, and we're just as excited as you are to see your continued results with fine lines and wrinkles. Your appreciation of our streamlined, easy-to-use system truly validates our commitment to creating effective, uncomplicated skincare solutions. Your trust in our products means the world to us, and we're deeply grateful to have you as part of the KaramMD Skin community. Thank you for sharing your inspiring experience with us!

  • CS
    Christina S.
    Verified Buyer
    19 hours ago
    Rated 5 out of 5 stars
    Game changer

    I’ve used another high-end line for years & was happy with it. However, I was intrigued so tried Trifecta. Wow. I had no idea in a short amount of time, my skin could look even better than before! At 51, I’m a customer for life!!

    KS Profile picture for KaramMD Skin
    KaramMD Skin
    3 hours ago

    Thank you for your wonderful review, Christina ! We're absolutely thrilled to hear about your remarkable experience with Trifecta. It's particularly touching to hear how, even after being satisfied with another high-end skincare line, you've discovered even better results with our products—these are exactly the kind of transformative outcomes we aim for with our formulations. We love that at 51, you're experiencing such noticeable improvements in your skin in such a short time. Your commitment to making Trifecta a lifelong part of your skincare journey truly validates our dedication to creating exceptional skincare solutions. We're deeply grateful to have you as part of the KaramMD Skin community. Thank you for sharing your inspiring experience with us!