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4.7
Rated 4.7 out of 5 stars
1,955 Reviews

The KaramMD Trifecta is a simple skincare system proven to give you healthier, younger-looking skin in 3 easy steps—formulated to target all aspects of aging skin simultaneously.

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MD Formulated

Clinically Proven

Premium Ingredients

For All Skin Types

Cruelty Free

Clinically Proven to Fight Aging Skin

The Trifecta system visibly reduces signs of aging in as little as 4 weeks when used consistently. We adhere to the highest product standards and validate efficacy through rigorous third-party testing. After 8 weeks of usage, the clinical study proved:

100% of subjects had improvement in skin’s moisture.

100% of subjects had improvement in fine lines & wrinkles.

91% of subjects had improvement in skin’s firmness.

Clinically Proven to Fight Aging Skin

The Trifecta system visibly reduces signs of aging in as little as 4 weeks when used consistently. We adhere to the highest product standards and validate efficacy through rigorous third-party testing. After 8 weeks of usage, the clinical study proved:

100% of subjects had improvement in skin’s moisture.

100% of subjects had improvement in fine lines & wrinkles.

91% of subjects had improvement in skin’s firmness.

Easy As 1-2-3

  1. Rinse Daily Cleanser: Apply to wet skin, massage in circular motions, then rinse clean.
  2. Quench Vitamin C Serum: Apply 2 pumps to slightly damp face, eye area, and neck.
  3. Illuminate Anti-Aging Cream: Apply 3 pumps to face, eye area, and neck.

    Repeat this routine morning and night for a minimum of 3-6 months for visible, lasting change.

    HOW TO USE: KARAMMD TRIFECTA

Easy As 1-2-3

  1. Rinse Daily Cleanser: Apply to wet skin, massage in circular motions, then rinse clean.
  2. Quench Vitamin C Serum: Apply 2 pumps to slightly damp face, eye area, and neck.
  3. Illuminate Anti-Aging Cream: Apply 3 pumps to face, eye area, and neck.

    Repeat this routine morning and night for a minimum of 3-6 months for visible, lasting change.

    HOW TO USE: KARAMMD TRIFECTA

Key Ingredients

Rinse Daily Cleanser
  • Aloe Vera: Soothes discomfort and hydrates skin
  • Apple Amino Acids: Cleanse without stripping natural oils
  • Arnica Extract: Calms irritation and reduces redness
  • Broccoli Seed Oil: Supports skin barrier for moisture
  • Willowherb Extract: Provides antioxidant protection
  • Allantoin: Naturally exfoliates and reduces redness

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Quench Vitamin C Serum
  • Triple Vitamin C: Lightens dark spots & boosts natural glow
  • Sodium Hyaluronate: Deeply hydrates and plumps skin
  • Green Tea: Antioxidant protection and calms irritation
  • Willowherb: Balances oil production and calms redness
  • Licorice Root: Brightens skin and reduces discoloration
  • Panthenol: Stimulates collagen production & skin repair
  • Aloe: Hydrates, soothes, and helps reduce skin irritation
  • Vitamin E: Strengthens defenses against premature aging
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Illuminate Anti-Aging Cream
  • Encapsulated Retinol: Works deeply to reduce fine lines and wrinkles
  • Niacinamide: Balances skin tone and refines texture
  • Peptide Complex: Supports the natural repair process
  • Lipid Complex: Enhances elasticity and skin barrier
  • Sodium Hyaluronate: Boosts hydration to reduce fine lines
  • Botanical Lighteners: Naturally reduce pigmentation
  • Edelweiss Flower Extract: Firms and protects skin
  • Squalene: Strengthens the barrier and locks in moisture
  • Hibiscus Flower: Supports body’s natural growth factors
  • Vitamin C & E: Antioxidants for skin protection and repair

View all ingredients

What to Expect from Trifecta

At the core of Trifecta's success is Dr. Karam’s skincare philosophy, the 3 Cs: Commitment, Consistency, & Continuity. Commit to daily skincare, apply it consistently twice a day, and continue month after month. The payoff? Smoother, firmer, brighter skin that builds over time. 

Laying the Foundation for Healthy Skin

Your First Month

The first month focuses on surface-level hydration, environmental protection, and early stages of cellular turnover. Results may be subtle, but your skin is hard at work repairing past damage and beginning to interact with active ingredients in preparation for transformation.

Clinical results at 4 weeks showed:

  • 94% showed improvement in fine lines and wrinkles.
  • 100% showed improvement in skin firmness.
  • 97% showed improvement in moisture.

CONSISTENCY

Month 2

By 8 weeks, the cumulative effects of consistent skincare become unmistakable. Collagen-supporting ingredients help reduce fine lines and wrinkles, while hydration levels reach new heights. Your skin barrier is stronger, texture is refined, and radiance is noticeably enhanced.


Clinical results at 8 weeks showed:

  • 100% showed significant improvement in skin’s moisture
  • 100% agreed skin looked more glowing
  • 100% showed significant improvement in fine lines
  • 100% saw improvement in skin’s texture
  • 100% agreed skin felt softer

CONTINUITY

3-6 Months

At the 3-month mark and beyond, your skin’s transformation deepens. Active ingredients continue to stimulate natural collagen production, supporting elasticity, increasing firmness, and making your skin more resilient against signs of aging.

Long-term use of active ingredients like retinoids, antioxidants, and peptides continue working at the cellular level to repair and restore past damage, stimulate skin renewal, and keep your skin functioning at its best.

Benefits compound with every cycle of Trifecta, meaning the longer you stay consistent, the better your skin will look and feel.

DEDICATION

Changes That Build Over Time

A subscription is the fastest path to real results.

By placing your routine on a long-term subscription, the essentials are delivered to your door, making it easy to build momentum. Applying skincare morning and evening means you get the optimal dose of active ingredients, and avoid any setbacks in progress that come from skipping applications.

When skincare becomes a permanent part of your lifestyle, results don’t just last, they transform. While we can’t slow down time, we can delay the visible signs of aging that come with it.

Your biological age is how your skin appears and functions. This number can be years younger than your chronological age with consistent care. With this approach, age truly becomes just a number, and your skin can look as young as you feel.

Put Your Routine on Autopilot

  • Stay Stocked

    Automatic delivery means you’ll never run out or lose momentum.

  • Stay Consistent

    Use morning and night without interruption for clinically proven improvement.

  • See Results

    Save 20% on every order and enjoy exclusive perks that reward your commitment.

WHY CONSISTENCY IS KEY

Skincare works like fitness: The more consistent you are, the stronger your results become. Every day you commit to your routine, your skin gets healthier, brighter, and more resilient.

Consistency chart showing improvement over months
Read the KaramMD Journal

Skincare Advice You Can Trust

Best anti-aging skincare ingredients to try

The Best Anti-Aging Ingredients

When assessing your skincare products, it is essential they include the following anti-aging ingredients. Each of these ingredients play a unique role in skin health and are crucial to achieving y...

Dr. Amir Karam, founder of Karam MD Skincare

Dr. Karam's Philosophy for an Effective Skincare Routine

I believe I’ve finally found the secret to anti-aging. After 20 years of experience—and a lot of patience (and patients) throughout my career—I came to understand that skincare is more than just t...

KaramMD Trifecta skincare routine: Rinse Daily Cleanser, Quench Vitamin C Serum, and Illuminate Anti-Aging Cream held in a single hand.

Trifecta 101: What You Need to Know When Starting Your New Skincare Routine

Whether you’re completely new to skincare or transitioning to the Trifecta system, this guide will walk you through what to expect as you begin your skincare journey.

Great Skin Made Simple

The Trifecta was developed by world renowned skin and facial rejuvenation expert Dr. Amir Karam. This routine is formulated with only the best high-quality ingredients, and designed to deliver results that only get better over time. Learn more about the creation of the Trifecta. 

Great Skin Made Simple

The Trifecta was developed by world renowned skin and facial rejuvenation expert Dr. Amir Karam. This routine is formulated with only the best high-quality ingredients, and designed to deliver results that only get better over time. Learn more about the creation of the Trifecta. 

Aloe Barbadensis (Aloe Vera) Leaf Juice*, Aqua/Water/Eau, Lauryl Glucoside, Glycerin, Cocamidopropyl Betaine, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Allantoin, Sodium Cocoyl Apple Amino Acids, Brassica Oleracea Italica (Broccoli) Seed Oil, Epilobium Angustifolium (Fireweed) Flower/Leaf/Stem Extract, Cocamidopropyl Dimethylamine, Arnica Montana (Mountain Arnica) Flower Extract, Phenoxyethanol, Sodium Chloride, Caprylyl Glycol, Hexylene Glycol, Sodium Hydroxide, Ethylhexylglycerin, Sodium Phytate, Glycolic Acid, Dimethylaminopropylamine, Dichloroacetic Acid, Tetrasodium Glutamate Diacetate, Alcohol, Sodium Metabisulfite, Fragrance/Parfum, Limonene, Geraniol, Hexyl Cinnamal, Linalool.*Organic Ingredient

Frequently Asked Questions

Our caring team of experts has the answers.

4.7
Rated 4.7 out of 5 stars
Based on 1,955 reviews
Slide 1 selected
1,955 reviews
  • BP
    Bridget P.
    Verified Buyer
    What are your skin concerns? Fine Lines & Wrinkles, General Aging, Loss of Elasticity , Congested Pores , Uneven Skin Tone / Discoloration
    22 seconds ago
    What are your skin concerns? Fine Lines & Wrinkles, General Aging, Loss of Elasticity , Congested Pores , Uneven Skin Tone / Discoloration
    Rated 5 out of 5 stars
    BEST SKINCARE ROUTINE

    Karam MD Trifecta is the perfect skincare routine for me. I have used so many skincare products from Zo, Revision and SkinCeuticals and SkinMedica, which are all good but difficult routines to follow and maintain with all the different steps to follow. I love the simplicity of the routine coupled with the effectiveness of the products. I recently had facelift with CO2 laser and have been very happy with how these 3 simple steps have had such an amazing impact on maintaining my investment in my skin.

  • JN
    James N.
    Verified Buyer
    What are your skin concerns? Fine Lines & Wrinkles, Loss of Elasticity
    12 hours ago
    What are your skin concerns? Fine Lines & Wrinkles, Loss of Elasticity
    Rated 5 out of 5 stars
    Amazing Product !

    I'm 6 weeks into the daily regiment, and the results are very noticeable. I'm looking forward to a 90 day photo comparison I took.

    Comparing to Obagi and Lamar, I'm Impressed !

  • K
    Kimberly
    18 hours ago
    Rated 5 out of 5 stars
    5 Stars

    Simple. Just lovely

  • YS
    Yasmine S.
    Verified Buyer
    What are your skin concerns? General Aging
    Yesterday
    What are your skin concerns? General Aging
    Rated 5 out of 5 stars
    Amazing !

    I share Trifecta with my French friend. She tried it and saw the huge différence using thèse products.

    her skin looks so différent , So soft and firm in the Same Time. With a big glow..

    She finds that it s so easy to use when travelling.she is fond of the brand!

    Every 2 months I bring the products for her.

    Really a very good product.

    Thanks