My journey began with a defining moment. As a child, I watched my mother undergo a heart transplant — a profound experience that shaped my life’s purpose. From that moment on, I knew I wanted to become a surgeon. I set my sights on medicine with unwavering focus, graduated at the top of my class at UC San Diego, and started medical school in 1997 at UC Irvine. By 2001, I had committed myself to facial plastic surgery, diving into clinical and laboratory research that laid the foundation for everything I do today. I graduated top of my class in 2005 and went on to complete a prestigious facial plastic surgery fellowship.

Since then, I’ve spent over two decades relentlessly dedicated to helping people look as young as they feel. As a double board-certified facial plastic surgeon, I’ve performed thousands of facial rejuvenation procedures and pioneered the Vertical Restore® technique — now considered among the most advanced and natural-looking facelift procedures in the world. Patients fly in from every corner of the globe to see me because of one thing: trust.

But surgery is only one piece of the puzzle.

Since 2001, I’ve also been obsessed with the question of skin aging — not just how it looks, but why it happens, how it affects us emotionally, and how to reverse it in a meaningful and lasting way. I didn’t accept surface-level answers or follow the skincare status quo. I dove into the physiology, the science, the literature — teaching myself, rather than just accepting what was commonly repeated. What I discovered changed everything: skin aging is multifaceted, and treating it effectively requires a comprehensive, daily approach using the right actives — all of them, not just a few.

For over a decade in private practice, I watched my patients struggle with overwhelming routines: 8 to 10 products, complicated layering, harsh reactions, rising costs. Even the most committed patients couldn’t sustain it. And most products on the market were missing key components — or worse, pushing marketing over science. I knew this had to change.

That’s when the idea for the KaramMD Trifecta was born.

In 2016, I envisioned a skincare solution that was simple, comprehensive, and clinically effective — something that combined every essential active needed to combat skin aging at its root, and was gentle enough for daily use by all skin types. We started formulating and I personally oversaw every step of the research and development, ensuring it met the same standards I demand in my surgical work.

After 3.5 years of testing, refining, and third-party clinical trials, the Trifecta launched in 2021. It’s not just a product — it’s a prescription-level solution to one of the most emotionally impactful aspects of aging. It combines the highest-quality actives — including retinol, peptides, antioxidants, skin brighteners, hydration factors, and more — in a simple three-step routine that’s as easy to follow as brushing your teeth. And it works. The clinical results were off the charts. Nearly 11,000 people now use it daily, and their glowing feedback mirrors what I’ve seen in my patients: confidence, clarity, and results.

KaramMD was born from my core belief: people deserve better. Better answers, better products, better results — without having to do years of research themselves. We do the hard part. We dive deep into science, history, data, and physiology — and we bring you the truth. That’s our brand identity: deep inquiry with real solutions. In a world filled with noise, confusion, and marketing hype, we are a trusted guide.

This is not a corporate skincare line. We don’t chase trends. We solve problems. We are patient-first, always. That’s the same integrity I’ve built my entire surgical reputation on — and it’s the same spirit behind everything we do at KaramMD.

Because when you look as young as you feel, you get to keep being you. And that, to me, is the most important result of all.

— Dr. Amir Karam

Founder, KaramMD