4 Pro Secrets to Defy Skin Aging

Amir Karam MD Founder / Creator KaramMD

Let’s talk about whether it’s possible to have skin that looks like you’re in your 30s when you’re in your 40s, 50s, 50s and beyond. Skin is 100% in your own control. You actually have full power over defying age. Here are some secrets that can help you obtain vibrant, fresh skin now and until you’re well past middle age.

What can you do right now that will impact how your skin ages forever?

In my work as a facial plastic surgeon over the last twenty years, I have worked with thousands of people. I noticed there is a sub-group of people who have basically ageless-looking skin. Their skin is clear, vibrant, luminous, supple, balanced, and strong. How can this be possible with people in the 60s and 70s? It is like their skin doesn’t age. Of course, genetics has something to do with it, but it’s more than that.

Over the years, I interviewed these patients and isolated the commonalities they shared. They all had two things in common: avoiding sun exposure and using active ingredients on the skin. These are the first two pro secrets to defying skin aging:


While being in the sun for about 15 minutes a few times a week is enough to get the vitamin D you need, most people overdo this. If you expose your skin to the sun too much over the years, you are opening up your skin to the number one aging accelerator.

The cells retain the sun exposure over time as cell memories. The cells that control pigmentation and collagen production begin to express the cumulative exposure of the sun. As the years pass, this comes out as accelerated skin aging: collagen loss, wrinkles, hyperpigmentation and other changes. I get into this in much more detail in my video that explains more about how this aspect of skin aging works.


Active skin ingredients work at the level of DNA to keep the skin healthy, beautiful and strong. What are the ingredients that you need to apply to your skin to reverse the signs of age and increase the strength, thickness, elasticity and health of your skin?

These active ingredients work at the cellular level to increase collagen production and keep your skin stronger, thicker, smoother and clearer:

  • Retinoids
  • Vitamin C
  • Growth Factors
  • Niacinamide
  • Hyaluronic acid

What to expect when you use Retinol

When you first start using Retinol, the skin starts to get red, inflamed, and flaky or peeling. Seeing this, many people stop using it or rarely use it. The way Retinol should be used begins with three times a week. There will be a period of change as your skin reacts to it. If you can push through it, the results are well worth it. Then, build up to using it every day by the time a couple of weeks pass.

However, most people are not willing to go through this period of time and don’t want to deal with the red, inflamed, flaking skin. The best thing to do in this case is to use products that have microdoses of Retinol. Combining vitamin C, an anti-inflammatory, and an enriching moisturizer, are also key to using Retinol properly. Together, they work with synergy to achieve beautiful effects.

What are the other ways to defy skin aging?

Aside from sun protection and the vital active ingredients you need on your skin on a daily basis, there are two other important tips to think with:


Periodic skin treatments help boost collagen production and keep your skin healthier and more radiant. I recommend chemical peels, microneedling, and light laser treatments that cause micro-injuries, stimulating the skin to build more collagen.


All the best and most expensive skincare products in the world won’t achieve your goals unless you use them consistently. One of the problems I ran into with my patients who wanted to achieve beautiful skin was the fact that they had so many different products and had such a complex skincare routine that they couldn’t keep up with it consistently.

That’s why I created the TRIFECTA, so that every ingredient that I mentioned here, and more, was easily available in a simple skincare program. But whether you use the TRIFECTA or your own products with these ingredients, be consistent! Keep going and use these ingredients on your skin every day.


I created the TRIFECTA to provide my patients with a simple skincare line that they could trust. The TRIFECTA includes all the vital ingredients for beautiful skin, but it doesn’t require a complicated routine that can’t realistically be maintained with consistency. While there are some great products out there, I couldn’t find them available in a simple, sustainable routine you can maintain consistently, without fail.

I wanted to find a solution to this, so I spent five years formulating the KaramMD TRIFECTA. The TRIFECTA is a simple, three-product skincare routine packed with the vital ingredients needed to reverse the aging process. The TRIFECTA is clinically proven to achieve supple, radiant, youthful skin. It includes the following products:


A hydrating, refreshing cleanser that softens the skin as it removes toxins and triggers cell regeneration. RINSE is also designed to help prevent UVA damage and prepare your skin to absorb the active ingredients in the other products of the TRIFECTA line.


QUENCH is a skin-brightening vitamin C serum that helps to prevent collagen breakdown and renews the skin, reducing fine lines, hyperpigmentation, and other signs of age.


An anti-aging cream that can be used as an all-in-one product or together with RINSE and QUENCH to achieve a range of positive effects. ILLUMINATE improves skin elasticity, deeply hydrates and moisturizes, and boosts collagen production and cell turnover to achieve more vibrant, luminous skin.

In addition to the TRIFECTA, I created an exfoliator to get rid of dead skin and buildup on the skin’s surface: POLISHPOLISH gently evens the skin texture and smooths the skin by removing dead cells and toxins at a deeper level. POLISH also regulates oil production and improves skin hydration.

Your skincare expert, Dr. Amir Karam

Dr. Amir Karam has over two decades of experience as a double board-certified facial plastic surgeon who achieves beautiful, youthful-looking results for his patients. After working with hundreds of people who wanted to look as young as they felt, Dr. Karam realized patients needed more than custom facial surgery and the available skincare products on the market to truly achieve a youthful, fresh appearance. Dr. Karam found that patients were commonly overwhelmed with the multi-step skincare products available, and many products lacked the necessary ingredients to properly revitalize their skin. Dr. Karam wanted to provide a truly excellent yet simple skincare line to help his patients achieve the glowing, youthful skin they desire with an easy-to-follow skincare routine.

Dr. Karam developed the clinically proven, groundbreaking TRIFECTA, a skincare line packed with all of the ingredients required to achieve beautiful, healthy skin with three simple steps. The TRIFECTA is effective and safe for all skin types, resulting in vibrant, luminous skin. With Dr. Karam’s TRIFECTA + POLISH, you have everything you need to achieve beautiful skin in an easy routine.

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