Is it Too Late to Start Using Retinol?

By: Amir Karam MD

A question I hear a lot is, “Is it too late to start using retinol?” Patients in their late 40s, 50s and 60s often wonder if retinol will benefit them at their age, and they ask me if it’s simply too late to try this skincare product.

The answer is: absolutely not. It is definitely not too late to start using retinol, whatever your age. I get into this in more detail in my ig video, but essentially, retinol is one of the most vital ingredients when it comes to getting the beautiful, healthy skin you want.


What is Retinol?

Retinol is a derivative of vitamin A. This ingredient is commonly used in skin care products because of its anti-aging effects. If the dosage of retinol is too high, it can cause a reaction in the skin when you first use it, such as redness or dryness and peeling. This can put people off of using retinol, but the key is consistency–keep using it. As your skin adapts, you will notice outstanding results. Products that include micro amounts of retinol can also be used that produce a minimal reaction in its initial phase and achieve excellent results.

What Does Retinol Do For Your Skin?

Retinol has both short and long-term benefits for the skin. It improves the skin more and more over time. Retinol achieves the following benefits for your skin:

  • Stimulates collagen
  • Boosts the rate of cell turnover
  • Exfoliates the surface of the skin
  • Brightens and smooths the skin
  • Helps unclog pores
  • Helps clear away acne
  • Reduce hyperpigmentation
  • Strengthen the skin barrier
  • Achieve better skin hydration

It’s Never Too Late to Start Using Retinol as an Addition to Your Skincare Routine 

At any point in life, retinol is a positive ingredient for your skin, ultimately achieving outstanding results. You will start to see short-term improvements, and these will expand into long-term benefits over time. In general, the combined effects of retinol improve youthful facial volume and reduce wrinkles and fine lines, giving your skin a more radiant, fresh look and a plumper appearance. 

This is why I included a microdose of retinol in the TRIFECTA, my skincare line. With the TRIFECTA, you are applying a small dose of retinol to your skin daily, just enough to get the effects you want for your skin, but not enough to result in significant side effects.

Retinol is a key ingredient in the ILLUMINATE product, which can be used twice a day as a part of the three-step TRIFECTA skincare routine or as a stand-alone product, morning and night.


The TRIFECTA is a simple, three-step skincare line that includes a range of vital ingredients necessary for achieving beautiful skin, including retinol. Used together with the exfoliator POLISH, the TRIFECTA provides everything your skin needs to be as beautiful, healthy, and youthful as you want it to be. 

I created the TRIFECTA and POLISH because I wanted to give my patients a way to achieve radiant, fresh skin without dealing with a complicated skincare routine. I looked for the right products for years and discovered that not only was the selection of products overwhelming, but many didn’t have what is needed for beautiful skin. And worse, the required steps and complexity of many of the great skincare products that were out there made it almost impossible to follow the skincare routine consistently on an everyday basis, which must be done to get results.

How does the TRIFECTA + POLISH work?

The TRIFECTA and POLISH are four groundbreaking skincare products that are each clinically proven to achieve youthful, supple and radiant skin. The TRIFECTA should be applied twice every day. Apply 1-2 pumps of each product to the skin of your face, neck, and around your eyes in the morning and night.


This refreshing cleanser hydrates and softens the skin, removing toxins and makeup residue. RINSE triggers cell regeneration and helps to prevent UVA damage. This product prepares your skin for deep absorption of the active ingredients of the other KaramMD skincare products.


This brightening vitamin C serum helps renew and rejuvenate the skin, preventing collagen breakdown and reducing hyperpigmentation, fine lines, and other signs of age. 


This anti-aging cream includes retinol and a range of many other vital ingredients for beautiful, ageless skin. The ingredients of ILLUMINATE stimulate skin elasticity, boost collagen production and cell turnover, hydrate and freshen the skin, and achieves radiant, luminous effects. ILLUMINATE works together with RINSE and QUENCH to achieve beautiful, youthful skin. 


This gentle but highly effective exfoliator removes dead skin cells and toxins and other buildup to improve skin hydration, smooth skin texture, regulate natural oil production, and plump the skin for a clear, radiant, vibrant appearance.

Your skincare expert, Dr. Amir Karam

Dr. Karam is a double board-certified facial plastic surgeon who has spent more than two decades achieving beautiful, youthful-looking results for patients. He has helped hundreds and hundreds of patients to combat the effects of the aging process. With his range of innovative surgical procedures and non-surgical treatments, Dr. Karam’s many satisfied patients consider him to be the “go-to” when it comes to turning back time and achieving a youthful, beautiful appearance.

Aside from surgical and non-surgical procedures and treatments he provides, Dr. Karam realized patients needed a home skincare routine to truly achieve the radiant, healthy, and vibrant skin that signals youth. 

Dr. Karam searched for the perfect skin products to recommend to his patients, but he soon realized the right products weren’t available or that the best products often required a complex routine that couldn’t realistically be followed every day. His patients needed a simple routine that could be followed both morning and night consistently. 

Dr. Karam wanted to provide a truly excellent yet simple skincare line to help his patients achieve the glowing, youthful skin they desired with an easy-to-follow skincare routine. This led him to research and formulate the TRIFECTA + POLISH. These clinically proven, groundbreaking products have all the necessary ingredients needed for beautiful skin. His products are safe for all skin types, work for patients at any stage of the aging process, and can be consistently applied with an easy, short morning and night routine.


  • KaramMD Customer Support Team

    Hi Mariel,
    Yes, Dr.Karam’s clinical office does carry the Trifetca!

  • Mary Jane Young

    I have been using your trifecta since October 2022, and I must admit I was surprised how effective it has been. For years I have tried using retinal products, but always dealt with major flakiness and discomfort, now with Dr. Karam’s skincare products, not only have my dark spots been greatly reduced, but my overall skin appearance is remarkable!! I have had many people comment on my complexion!

  • Mariel

    Does your office carry the Trifecta?

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