What Is Retinol and How Does It Work for Anti Aging?
Retinol is a vitamin A derivative that converts in the skin to retinoic acid. This active form binds to skin cell receptors and triggers:
- Increased collagen production
- Accelerated cell turnover
- Smoother skin texture
- Reduction in fine lines and wrinkles
- Improvement in discoloration and sun damage
It works at a cellular level, which is why it remains one of the most powerful topical anti aging ingredients available without a prescription.
However, the way retinol is delivered into the skin dramatically impacts both results and irritation. Traditional retinol is highly effective, but it has limitations. It absorbs rapidly and releases all at once. That immediate delivery can overwhelm the skin barrier, leading to redness, peeling, dryness, sensitivity, and inflammation.
Additionally, traditional retinol can be unstable. It degrades when exposed to light, air, and heat, which means it doesn't work well for daytime use, and can reduce potency over time if not carefully formulated and stored.
Many people abandon retinol before reaching its long term collagen stimulating benefits simply because the irritation phase feels discouraging.
That is where encapsulated retinol changes the experience.


























4 comments
MICHELLE GARRETT
I always thought that using tretinoin would give you better results over retinol . Why aren’t you recommending this in your approach to skin care?
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KaramMD Skin replied:
Hi Michelle—Thank you for your comment! Tretinoin wasn’t included here because it requires a prescription but we do have plans to cover it in a future journal article!
Barbara Daros DaRos
Does it tighten up a 72 year old hanging neck ? I wish I had the money to see you. You probably hear this all the time . You sir are a master . I have never in my life seen work like yours . I’ve had 3 different cancers and a hysterectomy which took all my hormones away .Is there any advice to revive my skin ? Will your product help ? Your hands are gold 😊❤️
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KaramMD Skin replied:
Hi Barbara—Thanks for your comment! Your strength and honesty are truly inspiring. To be real, no non-surgical treatment can truly tighten skin laxity, especially in the neck. If they could, surgery wouldn’t be necessary. That said, great skincare can absolutely support your skin’s health, radiance, and texture. We’re here for you if you ever have questions or need guidance. 💛
Karen Henselwood
I have been using prescription Retin-A .1% and compounded Retin-A .1% and Retin-A .05%. My forhead, cheeks and under my eyes look great but my chin has wrinkles. I do not drink out of a straw. I do not expose my skin to the sun at all. I wear about 8 serums during the day with sunscreen. Lasers I have done but still wrinkles on the chin. I do dysport on my chin as well. I am 65. Any other suggestions.
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KaramMD Skin replied:
Hi Karen—Thanks for your comment! It sounds like you’re doing many of the right things. The chin can be a stubborn area, especially as collagen and structural support diminish with age. At 65, volume loss and deeper tissue laxity often play a bigger role than surface treatments can address. You may benefit from targeted collagen-stimulating procedures like RF microneedling or even subtle structural support with fillers or fat transfer, depending on your anatomy. A personalized evaluation would help guide the next best step. Keep up the great work with your regimen!
Suad Picardi
I think Dr Karam is a genius! I love his approach to skincare and plastic surgery when it’s the right time! I’ve always been interested in skincare and would love to pick his brain on Retin A?
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KaramMD Skin replied:
Hi Suad—Thanks for your comment! Retinal (Retin A) is generally considered more potent and faster-acting than retinol, as it requires only one step to convert into retinoic acid, the active form of Vitamin A. While it can be effective, due to its higher potency, retinal may be more likely to cause irritation, redness, or peeling, especially when first introduced to the skin. Retinol, with its slower conversion, is often better tolerated. This is why Dr.Karam chose to use an encapsulated, slow-release Retinol in Illuminate which allows for more consistent use while still delivering results.
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