Understanding Growth Factors: What They Are and How They Work in Skincare

Amir Karam MD Founder / Creator KaramMD

What happens to the skin as it ages? Collagen production decreases, so you see lines, wrinkles, laxity, and dull skin. If we don’t stimulate collagen production as we age, our skin starts to look older and duller–the skin is on a downward slope.

So, how do growth factors fit into boosting collagen? Are growth factors an essential ingredient in your skincare routine?

How growth factors work

Growth factors are proteins naturally produced and found in the body that stimulate cell growth and function. They trigger cells to divide, grow, and produce collagen, the basic building block of skin. These proteins also bind to cell receptors and communicate crucial messages, such as “produce collagen” or “create more elastin.” These are called “fibroblasts.”

Aging causes us to lose about 1% of our fibroblasts and 1% of our skin’s thickness yearly. The age-related loss of fibroblasts produces fewer new cells, less collagen, and fewer growth factors. The remaining fibroblasts are also less sensitive to the growth factors present, resulting in thinner, wrinkled skin.

When applied topically, growth factors help improve the appearance of aging skin by reversing some of the reduced cell growth and collagen production. These collagen stimulants target fibroblast production and trigger collagen growth at the cellular level. Increased collagen production thickens the skin and reduces wrinkling to minimize the effects of aging-related changes and keep the skin strong and smooth.

Growth factors are an important ingredient in your skincare routine

The purpose of growth factors in skincare is to act as a healing agent that encourages cells to produce components that:

  • Improve skin firmness and elasticity
  • Strengthen the skin barrier
  • Repair and rejuvenate skin

Skincare products that get down to the cellular level and trigger the cells that boost collagen production can turn on the collagen “engine” and rebuild collagen growth over time. The entire reason for putting skincare products on your face is to get your cells to produce collagen again.

When I formulated the TRIFECTA, I wanted to develop a product that stimulated collagen for the long run and was easy to use daily to reverse collagen loss over time. Growth Factors are a crucial ingredient that helps stimulate collagen production over time, so I added a botanical growth factor that works on the cells that create and produce collagen.


It is so important to stay consistent with the KaramMD TRIFECTA because the longer you use it, the better results you will see, and the longer the growth factors will impact your skin and anti-aging. We simplified your skincare routine so you can start it… and stay on it forever!

I built these products around the core concept of getting the body to produce collagen again at a new level. The TRIFECTA daily skincare routine involves three easy steps:

  1. RINSE: A gentle cleanser that softens and hydrates the skin to boost cell regeneration and collagen production, prevent UV damage, and prepare the skin to absorb active skincare ingredients.
  2. QUENCH: An anti-inflammatory, brightening vitamin C serum that minimizes fine lines and prevents collagen breakdown in the skin.
  3. ILLUMINATE: The all-in-one anti-aging cream that boosts cell turnover and collagen production, improving skin elasticity, reducing signs of age, deeply hydrating, and firming the skin for a supple, youthful glow.

Dr. Amir Karam, double board-certified facial plastic surgeon

Dr. Amir Karam is a world-renowned facial cosmetic surgeon. As an authority in his field, he provides over two decades of experience helping patients achieve radiant, refreshed, youthful skin.

In his work as a facial plastic surgeon creating a defined facial shape, Dr. Karam wanted to help his patients achieve fresh, vibrant skin, the other vital aspect of a youthful appearance. His patients were often overwhelmed with a broad selection of products and complicated skincare routines.

Dr. Karam spent over five years creating the TRIFECTA, a simple yet groundbreaking skincare line for all skin types. His easy-to-use, potent products are clinically proven to achieve beautiful, healthy skin.

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